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KMID : 1144020070030010026
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Journal of Korean Association for Disability and Oral Health
2007 Volume.3 No. 1 p.26 ~ p.30
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DENTAL MANAGEMENT OF LEUKOCYTE DEFICIENCY IN A CHILD WITH SEVERE ORAL INVOLVEMENT
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Kim Hyun-Jin
Lee Nan-Young
Lee Sang-Ho
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Abstract
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Leukocyte adhesion deficiency(LAD) is a rare autorecessive defect of phagocytic function resulting from a lack of leukocyte cell surface expression of integrin molecules(CD 18) that are essential for leukocyte adhesion to endothelial cells and chemotaxis. As a results, patients with LAD suffer from severe bacterial infections and impaired wound healing. A small number of patients with leukocyte adhesion deficiency-1 have a milder defect, with residual expression of CD18. These patients tend to survive beyond infancy; they manifest progressive severe periodontitis, alveolar bone loss, periodontal pocket formation, and partial or total premature loss of the primary and permanent dentitions. In this report, we report on a 7 year old girl with severe oral involvement. The most import focus should be to control infections to reduce the risk for future infection.
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KEYWORD
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Leukocyte, Adhesion, Periodontitis
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